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diagnosis hepatology lfts causes hepatitis transaminitis acidosis aflp alkaline alp bilirubin chemistry classification comparison conjugated dehydrogenase direct disease elevated enzymes
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Liver Function Test ... (LFTs) Elevation ... specific for the liver ... #FunctionTest # ... LFTs #Elevation
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
Phosphatase (ALP) Elevation ... - Differential ... Other causes of elevation ... consult ALP elevation ... Phosphatase #ALP #Elevation
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
Abnormal liver function ... tests algorithm ... magnitude of enzyme elevation ... normalised ratio; LDH, lactate ... #Differential #
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Elevation, Lactic ... Acidosis - Differential ... Elevation Type ... Lactic #Acidosis #Elevation ... #Differential #
Approach to Conjugated Hyperbilirubinemia - Differential Diagnosis Algorithm 1. Definition: T.bili elevation + >20% conjugated 2. Obtain RUQ
Hyperbilirubinemia - Differential ... Diagnosis Algorithm ... Definition: T.bili elevation ... MRCP, ERCP, liver ... #Diagnosis #Algorithm
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... Diagnosis Algorithm ... Bilirubin - +/- elevation ... Enzyme Elevation ... #diagnosis #algorithm
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Bilirubin - +/- elevation ... - If both are normal ... or amyloid: • Elevation ... Enzyme Elevation ... chemistry #diagnosis #differential
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
to 10-20-fold elevation ... Hepatic imaging: Normal ... • Histology: Normal-mild ... to 10-20-fold elevation ... hepatitis #comparison #differential
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Elevated Lactate ... Dehydrogenase (LDH) - Differential ... RBCs, muscle, liver ... upon damage • Normal ... Idiosyncratic LDH Elevation
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
levels - Usually normal ... products or D-dimer - Normal ... Mild-to-moderate elevation ... Serum lactate ... WBC count and differential
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