11 results
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
Function Test (LFTs) Elevation ... for the liver ALP ... SinaiBmoreIMRes #Liver #FunctionTest ... #LFTs #Elevation ... Transaminitis #diagnosis #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
phos/ULN ALP) ... Bilirubin - +/- elevation ... or amyloid: • Elevation ... of Liver Enzyme Elevation ... #differential #Hepatology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
) Elevation - Differential ... Other causes of elevation ... elevation DDX of ... #Elevation #Differential ... Diagnosis #Algorithm #hepatology
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury
Hepatocellular Liver Injury
 • AST/ALT elevation
Injury • AST/ALT ... elevation > Alk ... phos • ALT more ... • R value = (ALT ... #differential #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Bilirubin - +/- elevation ... disease - If ALP ... of Liver Enzyme Elevation ... hemolysis) • ALP ... diagnosis #algorithm #hepatology
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism
AST and ALT:
 • AST: liver
Chemistry Tests - AST, ALT ... Metabolism AST and ALT ... clearance - AP ... hepatocyte - Elevation ... AlkPhos #Bilirubin #Hepatology
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
ALP enzyme- Discovered ... in 1923 Low ALP ... eliminated • Elevation ... phosphate &/or • Elevation ... Hyophosphatasia #hepatology
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
to 10-20-fold elevation ... to 10-20-fold elevation ... of Pregnancy (AFLP ... Disease #Pregnancy #hepatology ... diagnosis #icp #HELLP #AFLP
Abnormal liver function tests algorithm.
 This figure details the initial response to abnormal liver blood tests.
box indicates all ... magnitude of enzyme elevation ... ALP, alkaline phosphatase ... ; ALT, alanine aminotransferase ... Abnormal #Algorithm #Hepatology
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
Anti-LKM & Anti-ALC ... (rare) - IgG Elevation ... immunosuppressive tx: - ALT ... > 10x ULN - ALT ... Diagnosis #Management #Hepatology