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diagnosis differential hepatology algorithm lfts causes hepatitis laboratory transaminitis alkaline alp bilirubin chemistry enzymes fever infectiousdiseases interpretation lactate phosphatase travel
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Liver Function Test ... (LFTs) Elevation ... specific for the liver ... #FunctionTest # ... LFTs #Elevation
Pulmonary Function Tests (PFTs) - Interpretation Algorithm • Normal • Pulmonary Hypertension, Anemia, Carboxyhemoglobinemia • Chest
#Pulmonary #FunctionTests
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Liver Enzymes (LFTs ... and Cholestatic Liver ... Hepatocellular Liver ... Injury • AST/ALT elevation ... or Cholestatic Liver
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
Phosphatase (ALP) Elevation ... disturbance (obstructed liver ... Highest • Bone • Liver ... Other causes of elevation ... consult ALP elevation
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Liver Chemistries ... Identify Acute Liver ... Bilirubin - +/- elevation ... or amyloid: • Elevation ... Enzyme Elevation
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
Liver Disease in ... to 10-20-fold elevation ... Hemolysis, Elevated Liver ... to 10-20-fold elevation ... clinical features: Liver
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... Causes of Acute Liver ... artery: Shock liver ... Bilirubin - +/- elevation ... Enzyme Elevation
C-REACTIVE PROTEIN Discovered by Tillett & Francis in 1930. First identified as a substance in the serum
synthesized by the liver ... Normal or minor elevation ... mg/L: Moderate elevation ... 10.0 mg/L: Marked elevation ... 50.0 mg/L: Severe elevation
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism AST and ALT: • AST: liver
Liver Chemistry ... ALT: • AST: liver ... In liver, 80% of ... primarily within liver ... hepatocyte - Elevation
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
Abnormal liver function ... response to abnormal liver ... derangement of liver ... the pattern of liver ... magnitude of enzyme elevation
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