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diagnosis hepatology algorithm lfts causes transaminitis abnormal alkaline alp elevated enzymes fever hepatitis infectiousdiseases lactate obstetrics phosphatase pregnancy travel acidosis
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Liver Function Test ... (LFTs) Elevation ... specific for the liver ... #FunctionTest # ... LFTs #Elevation
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
) Elevation - Differential ... disturbance (obstructed liver ... Highest • Bone • Liver ... elevation DDX of ... #Elevation #Differential
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Liver Chemistries ... Bilirubin - +/- elevation ... or amyloid: • Elevation ... Enzyme Elevation ... chemistry #diagnosis #differential
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
to 10-20-fold elevation ... to 10-20-fold elevation ... of Pregnancy (AFLP ... hepatitis #comparison #differential ... diagnosis #icp #HELLP #AFLP
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... • AST/ALT > ALP ... Bilirubin - +/- elevation ... Enzyme Elevation ... injury #hepatitis #differential
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Tests - Differential ... (ALT or AST > ALP ... Wilsons, Pregnancy - AFLP ... Cholestatic Pattern (ALP
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... of Pregnancy (AFLP ... hepatocytes → Liver ... infiltration) Differential ... iMedEducation #AFLP
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Liver Enzymes (LFTs ... and Cholestatic Liver ... Hepatocellular Liver ... Injury • AST/ALT elevation ... Transaminitis #diagnosis #differential
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
in 1923 Low ALP ... 1948 by Rathbun ALP ... synthesized in: liver ... eliminated • Elevation ... phosphate &/or • Elevation
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... - Differential ... • Pregnancy - AFLP ... #LiverEnzymes #Differential
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