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diagnosis differential hepatology lfts hepatitis alkaline alp anemia gastroenterology hematology lactate macrocytic macrocytosis management phosphatase transaminitis workup aafp acidosis aflp
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Liver Function Test ... (LFTs) Elevation ... specific for the liver ... #FunctionTest # ... LFTs #Elevation
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
Phosphatase (ALP) Elevation ... Intestine - Other causes ... of elevation: ... consult ALP elevation ... Phosphatase #ALP #Elevation
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
Mild jaundice, Elevated ... to 10-20-fold elevation ... Hepatic imaging: Normal ... Syndrome (Hemolysis, Elevated ... to 10-20-fold elevation
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Vascular Causes ... specificity to elevated ... Bilirubin - +/- elevation ... function may be abnormal ... Enzyme Elevation
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
specificity to elevated ... Bilirubin - +/- elevation ... - If both are normal ... or amyloid: • Elevation ... Enzyme Elevation
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... with elevated Mean ... Differential Diagnosis Algorithm ... Deficiency - Abnormal ... #Causes #Hematology
Causes of ST Segment Elevation - Differential Diagnosis Framework STEMI: • Upsloping convex STE: "Pardee's sign" +
Causes of ST Segment ... Elevation - Differential ... Diffuse ST-segment elevation ... segment becomes elevated ... blocking drugs #STElevation
Approach to Conjugated Hyperbilirubinemia - Differential Diagnosis Algorithm 1. Definition: T.bili elevation + >20% conjugated 2. Obtain RUQ
Differential Diagnosis Algorithm ... Definition: T.bili elevation ... non-ICU vs ICU causes ... MRCP, ERCP, liver ... Differential #Diagnosis #Algorithm
Causes of Hyperferritinemia - Differential Diagnosis Ferritin > 1000 Ferritin is the storage form of iron. Increased hepcidin
Causes of Hyperferritinemia ... is made in the liver ... Most Common Causes ... of elevated ferritin ... extreme ferritin elevation
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Elevation, Lactic ... equate that an elevated ... Causes of elevated ... Elevation Type ... Lactic #Acidosis #Elevation
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