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diagnosis hepatology differential transaminitis abnormal injury causes chemistry elevated enzymes hepatocellular interpretation liverenzymes liverfunctiontests rvalue
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Liver Function Test ... (LFTs) Elevation ... / ULN ALT) / (ALP ... #FunctionTest # ... LFTs #Elevation
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... • AST/ALT > ALP ... > AST/ALT: typical ... normal AST/ALT ... transaminitis #LFTs
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... Bilirubin - +/- elevation ... Tests of synthetic function ... Enzyme Elevation ... kidney, brain • ALT
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... or AST > ALP): ... • Severe - ALT ... • Moderate - ALT ... Burak @kwburak #LFTs
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
disproportionate increase in AST ... /ALT compared with ... compared with AST ... /ALT) Hepatocellular ... Transaminitis #LFTs
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... Severe ALT > 15x ... HELLP Moderate ALT ... • Others Mild ALT ... • Others #LFTs
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
Abnormal liver function ... should be requested at ... ; ALT, alanine aminotransferase ... disease; AST, aspartate ... #LFTs #Abnormal
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