15 results
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Idiosyncratic Drug-induced ... Liver Injury (DILI ... presentation • Chronic ... #Drug #induced ... gastroenterology #algorithm
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
Liver Function Test ... specific for the liver ... abnormality vs bone Bili ... SinaiBmoreIMRes #Liver ... #FunctionTest #
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Drug Induced Liver ... Stepwise Diagnosis Algorithm ... dechallenge • Acute or chronic ... e.g. ascites), Chronic ... Injury #Diagnosis #Algorithm
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... Liver Failure ( ... Hepatitis (AAH) Drug-Induced ... Liver Injury (DILI ... #ACLF #Acute #Chronic
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Elevated Liver Function ... Cirrhosis • Chronic ... (>1000): • DILI ... (Drug-induced liver ... LouLectures #Liver
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Differential Diagnosis Algorithm ... • Iatrogenic: DILI ... > 2 • NASH, Chronic ... injury: > 3 • Chronic ... differential #diagnosis #algorithm
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes
== Primary Skin Lesions ==
Macules /
Differential Diagnosis Algorithm ... Diabetes Mellitus Liver ... • Cholestatic liver ... Creatinine & BUN: • Chronic ... Differential #Diagnosis #Algorithm
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Drug Induced Lupus ... vs SLE Drug Induced ... Lupus (DIL): ... months to years) Systemic ... • Evolution: Chronic
Pediatric Vomiting - Gastrointestinal and Systemic Causes - Differential Diagnosis Algorithm
Hepatobiliary:
 • Acute Hepatitis
 • Acute
Gastrointestinal and Systemic ... Differential Diagnosis Algorithm ... Gastrointestinal - Chronic ... Gastrointestinal - Chronic ... Psychiatric: • Self-Induced
Nail Disorders secondary to Systemic Diseases
Nail Fold Abnormality
 • SLE
 • Scleroderma
 • Dermatomyositis
Koilonychia - Spoon-shaped
Disorders secondary to Systemic ... Grooves • Any systemic ... discoloration) • Liver ... discoloration) • Chronic ... Differential #Diagnosis #Algorithm