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diagnosis differential causes coagulation management prolonged bruising disorders hepatology treatment workup activation anemia chemistry classification dic disease disseminated hemophilia hemostasis
Causes of Prolonged PT (INR), Prolonged PTT • Prolonged PT (INR), Prolonged PTT • Prolonged PT
(INR), Normal PTT ... , Normal PT (INR ... , Normal PT (INR ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Algorithm for Investigation of Abnormal Coagulation Tests - Prolonged PT - Prolonged aPTT and Prolonged PT - Prolonged aPTT Dr.
Algorithm for Investigation ... of Abnormal Coagulation ... Tests - Prolonged PT ... and Prolonged PT ... #Hematology #Diagnosis
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
PT/NORMAL PTT: ... PT/ABNORMAL PTT ... ) ABNORMAL PT ... PT/ABNORMAL PTT ... Differential #Diagnosis #Hematology
Von Willebrand Disease - Most common inherited bleeding disorder Clinical • Easy bruising •
common inherited bleeding ... • Prolonged bleeding ... PT/INR • Normal ... aPTT (prolonged ... Disease #Diagnosis #Hematology
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm Suspected TMA: Unexplained thrombocytopenia + MAHA
and Management Algorithm ... /aPTT MAHA likely ... hemosiderin • PT ... /aPTT normal • ... #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... PT and/or aPTT ... Early liver disease ... #PT #aPTT #Prolonged ... #differential #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT ... Fibrinogen: ↓ • PT ... DIC • Severe Liver ... INR < 2.3 - APTT ... treatment #management #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
PT and the aPTT ... • Reduced liver ... amyloidosis #Abnormal ... #PT #aPTT #Prolonged ... #differential #hematology
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
established disease) • aPTT ... mixing study (aPTT ... may be normal in ... mild cases) • PT ... Management #treatment #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- History of bleeding ... epistaxis, gingival bleeding ... selected cases: INR/PT ... , aPTT(liver disease ... bypass), LFT (liver
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