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diagnosis hepatology differential injury lfts transaminitis aflp causes management obstetrics pregnancy aih autoimmune chemistry comparison dehydrogenase dili disease druginduced elevated
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Liver Function Test ... (LFTs) Elevation ... specific for the liver ... #FunctionTest # ... LFTs #Elevation
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... , Acute biliary ... obstruction, HELLP ... Diagnosis #Causes #Acute ... #algorithm #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... Differential Diagnosis Algorithm ... • Pregnancy: HELLP ... Bilirubin - +/- elevation ... Enzyme Elevation
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
to 10-20-fold elevation ... , no necrosis HELLP ... to 10-20-fold elevation ... and hemorrhage Acute ... hepatology #obstetrics #hepatitis
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
viral hepatitis ... viral hepatitis ... Bilirubin - +/- elevation ... Chronic viral hepatitis ... Enzyme Elevation
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Hepatocellular Liver ... • Infections: Hepatitis ... NAFLD, Autoimmune, HELLP ... Diagnosis #hepatology #algorithm ... Transaminitis #LFTs #hepatitis
Fever in Returning Travelers from Tropical Regions - Frequent Differential Diagnoses Medical History: • Skin exposure to
- HIV, herpes, hepatitis ... B, hepatitis C ... relapsing fever, acute ... Jaundice (and/or elevation ... , Lassa fever, acute
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... Differential Diagnosis Algorithm ... Pregnancy - AFLP, HELLP ... • Alcoholic hepatitis ... Differential #Diagnosis #Algorithm
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... hepatocytes → Liver ... headache, malaise) → Acute ... Diagnosis: Viral Hepatitis ... Preeclampsia, HELLP
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... dechallenge • Acute ... ascites), Chronic hepatitis ... • Autoimmune hepatitis ... Injury #Diagnosis #Algorithm
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