13 results
Causes of Prolonged PT (INR), Prolonged PTT
 • Prolonged PT (INR), Prolonged PTT
 • Prolonged PT
PTT, Normal PT ... (INR) - Bleeding ... ) - No Bleeding ... #PPT #PT #INR #Differential ... #Diagnosis #Algorithm
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm

Suspected TMA: Unexplained thrombocytopenia + MAHA
and Management Algorithm ... hemoglobin/hemosiderin, Hepatic ... antiglobulin test, PT/aPTT ... hemosiderin • PT/aPTT ... normal • DAT
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
dysfunction (25%) • Hepatic ... DIC • Severe Liver ... 100mg/dL) - Heparin ... INR < 2.3 - APTT ... < 1.5 x normal
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
PT/NORMAL PTT: ... PT/ABNORMAL PTT ... Acquired: • Heparin ... /NORMAL PTT: Suggests ... PT/ABNORMAL PTT
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Causes of Abnormal ... Early liver disease ... Reduced liver synthesis ... Jcortesizaguirr #Abnormal ... Causes #diagnosis #differential
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Differential Diagnosis ... Pre-analytical cause (e.g. heparin ... thrombin inhibitors, heparin ... • Reduced liver ... amyloidosis #Abnormal
Upper GI Bleed - Management Algorithm

Upper GI bleed Suspected: Melena, hematemesis, coffee-ground emesis, BRBPR
Initial Stabilization
Concern for
Bleed - Management Algorithm ... GI Bleed: • Peptic ... Disease • Variceal Bleeding ... GAVE (idiopathic, liver ... UGIB #GIBleed #Differential
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
Causes of Bleeding ... / Bruising - Differential ... Diagnosis Algorithm ... Destruction • Abnormal ... Iatrogenic) • Liver
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
- Differential ... Diagnosis Algorithm ... Injury: • Hepatic ... Venoocclusive disease • Hepatic ... RBC (hemolysis, bleeding
Causes of Abnormal Genital Bleeding - Differential Diagnosis Algorithm
Non-Gynecologic:
 • Medical (e.g. coagulopathy, liver disease, renal
Causes of Abnormal ... Genital Bleeding ... - Differential ... Diagnosis Algorithm ... coagulopathy, liver