11 results
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
Liver Function Test ... (LFTs) Elevation ... abnormality vs bone Bili ... #FunctionTest # ... LFTs #Elevation
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Acute Liver Injury ... Differential Diagnosis Algorithm ... • Hepatic vein: ... • Iatrogenic: DILI ... Enzyme Elevation
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... disease, Hepatic ... dechallenge • Acute ... presentation: Hepatic ... Injury #Diagnosis #Algorithm
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Bilirubin - +/- elevation ... replaced by non-hepatic ... or amyloid: • Elevation ... Enzyme Elevation ... Unconjugated Bili
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Elevated Liver Function ... Hepatopathy • Acute ... (>1000): • DILI ... (Drug-induced liver ... ) • Non-hepatic
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
to 10-20-fold elevation ... : <5 mg/dL • Hepatic ... to 10-20-fold elevation ... imaging: Hepatic ... and hemorrhage Acute
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
Differential Diagnosis Algorithm ... disturbance (obstructed liver ... Highest • Bone • Liver ... DDX of Hepatic ... Differential #Diagnosis #Algorithm
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Causes of Acute ... Autoimmune hepatitis, Acute ... Vasculature • Hepatic ... Congestion/CHF • Hepatic ... #algorithm #hepatology
Causes of Ascites - Differential Diagnosis Algorithm
Portal Hypertension - Prehepatic:
 • Portal vein thrombosis
 • Splenic
Differential Diagnosis Algorithm ... Hypertension - Hepatic ... Infiltrative disease • Acute ... liver failure ... Hypertension - Post-Hepatic
Commonly Observed Laboratory Findings in Hepatic / Liver Failure
 - Elevated conjugated and unconjugated bilirubin -
Laboratory Findings in Hepatic ... / Liver Failure ... ALT and AST - Elevations ... —100-fold with acute ... #LiverFailure #Hepatic