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diagnosis hepatology differential injury hepatitis lfts transaminitis alcoholic ascites bleeding bruising druginduced elevation hematology hemostasis hypertension management portal tests
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Liver Function Test ... specific for the liver ... abnormality vs bone Bili ... SinaiBmoreIMRes #Liver ... #FunctionTest #
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... for alternative causes ... disease, Hepatic ... dechallenge • Acute ... presentation: Hepatic
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Elevated Liver Function ... Hepatopathy • Acute ... (>1000): • DILI ... ) • Non-hepatic ... #Function #Tests
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... Vascular Causes ... of Acute Liver ... Injury: • Hepatic ... Tests of synthetic function
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... Vasculature • Hepatic ... Congestion/CHF • Hepatic ... Differential #Diagnosis #Causes ... #Acute #algorithm
Portal Hypertension - Differential Diagnosis Portal Pressure = the pressure difference between the pressure in the portal
synthetic function ... : • Cardiac causes ... • Cirrhosis/acute ... sarcoidosis) • Liver ... metastasis • Fatty liver
Causes of Ascites - Differential Diagnosis Algorithm Portal Hypertension - Prehepatic: • Portal vein thrombosis • Splenic
Causes of Ascites ... Differential Diagnosis Algorithm ... Hypertension - Hepatic ... Infiltrative disease • Acute ... liver failure
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
Acquired: • Heparin ... • Warfarin • Acute ... discern these causes ... are liver function ... disease • Acute
Alcoholic Hepatitis - Management Algorithm Assess Eligibility for Treatment: - Maddrey Discriminant Function ≥ (or possibly MELD
Maddrey Discriminant Function ... exclude other causes ... Treatment: - Acute ... HCV, DILI, HCC, ... acute pancreatitis
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