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diagnosis hepatology differential lfts transaminitis causes hepatitis injury alcoholic ascites bleeding bruising chemistry druginduced elevation hematology hemostasis hypertension interpretation management
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Liver Function Test ... specific for the liver ... abnormality vs bone Bili ... SinaiBmoreIMRes #Liver ... #FunctionTest #
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Elevated Liver Function ... Hepatopathy • Acute ... (>1000): • DILI ... ) • Non-hepatic ... #Function #Tests
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... disease, Hepatic ... dechallenge • Acute ... presentation: Hepatic ... Injury #Diagnosis #Algorithm
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... Differential Diagnosis Algorithm ... • Hepatic vein: ... • Iatrogenic: DILI ... Tests of synthetic function
Clinical manifestations of acute liver failure Brain: Hepatic encephalopathy, Cerebral edema, Intracranial hypertension,
liver failure ... Brain: Hepatic ... abnormalities Liver ... Loss of metabolic function ... #liver #failure
Portal Hypertension - Differential Diagnosis Portal Pressure = the pressure difference between the pressure in the portal
synthetic function ... including R heart failure ... • Cirrhosis/acute ... sarcoidosis) • Liver ... metastasis • Fatty liver
Causes of Ascites - Differential Diagnosis Algorithm Portal Hypertension - Prehepatic: • Portal vein thrombosis • Splenic
Differential Diagnosis Algorithm ... Hypertension - Hepatic ... Infiltrative disease • Acute ... liver failure ... : • Heart failure
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Mixed - Check Acute ... Liver Failure ( ... replaced by non-hepatic ... Unconjugated Bili ... > 90% of Total Bili
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
Acquired: • Heparin ... • Warfarin • Acute ... failure, disseminated ... function tests ... disease • Acute
Alcoholic Hepatitis - Management Algorithm Assess Eligibility for Treatment: - Maddrey Discriminant Function ≥ (or possibly MELD
Maddrey Discriminant Function ... Treatment: - Acute ... HCV, DILI, HCC, ... acute pancreatitis ... - Multiorgan failure
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