11 results
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
Liver Function Test ... specific for the liver ... abnormality vs bone Bili ... #FunctionTest # ... Transaminitis #diagnosis #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Elevated Liver Function ... Hepatopathy • Acute ... (>1000): • DILI ... ) • Non-hepatic ... #Function #Tests
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... disease, Hepatic ... dechallenge • Acute ... presentation: Hepatic ... #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Acute Liver Injury ... Differential Diagnosis Algorithm ... • Hepatic vein: ... Tests of synthetic function ... #hepatology
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Causes of Acute ... Autoimmune hepatitis, Acute ... Vasculature • Hepatic ... Congestion/CHF • Hepatic ... #algorithm #hepatology
Portal Hypertension - Differential Diagnosis
Portal Pressure = the pressure difference between the pressure in the portal
synthetic function ... • Cirrhosis/acute ... sarcoidosis) • Liver ... metastasis • Fatty liver ... Diagnosis #causes #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Mixed - Check Acute ... replaced by non-hepatic ... Unconjugated Bili ... > 90% of Total Bili ... #differential #Hepatology
Causes of Ascites - Differential Diagnosis Algorithm
Portal Hypertension - Prehepatic:
 • Portal vein thrombosis
 • Splenic
Differential Diagnosis Algorithm ... Hypertension - Hepatic ... Infiltrative disease • Acute ... liver failure ... #Hepatology #causes
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
Acquired: • Heparin ... • Warfarin • Acute ... function tests ... disease • Acute ... Differential #Diagnosis #Hematology
Alcoholic Hepatitis - Management Algorithm
Assess Eligibility for Treatment:
 - Maddrey Discriminant Function ≥ (or possibly MELD
Maddrey Discriminant Function ... Treatment: - Acute ... HCV, DILI, HCC, ... acute pancreatitis ... #hepatology