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diagnosis hepatology differential injury causes hepatitis laboratory lfts transaminitis aflp alkaline alp ascites chemistry comparison dehydrogenase dili disease druginduced elevated
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Liver Function Test ... (LFTs) Elevation ... specific for the liver ... #FunctionTest # ... LFTs #Elevation
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
to 10-20-fold elevation ... : <5 mg/dL • Hepatic ... to 10-20-fold elevation ... imaging: Hepatic ... and hemorrhage Acute
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... Differential Diagnosis Algorithm ... • Hepatic vein: ... Venoocclusive disease • Hepatic ... Enzyme Elevation
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
Differential Diagnosis Algorithm ... disturbance (obstructed liver ... Highest • Bone • Liver ... DDX of Hepatic ... Differential #Diagnosis #Algorithm
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... Autoimmune hepatitis, Acute ... Vasculature • Hepatic ... Congestion/CHF • Hepatic ... #algorithm #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Mixed - Check Acute ... Bilirubin - +/- elevation ... replaced by non-hepatic ... or amyloid: • Elevation ... Enzyme Elevation
Causes of Ascites - Differential Diagnosis Algorithm Portal Hypertension - Prehepatic: • Portal vein thrombosis • Splenic
Differential Diagnosis Algorithm ... Hypertension - Hepatic ... Infiltrative disease • Acute ... liver failure ... Hypertension - Post-Hepatic
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... disease, Hepatic ... dechallenge • Acute ... presentation: Hepatic ... Injury #Diagnosis #Algorithm
Commonly Observed Laboratory Findings in Hepatic / Liver Failure - Elevated conjugated and unconjugated bilirubin -
Laboratory Findings in Hepatic ... / Liver Failure ... ALT and AST - Elevations ... —100-fold with acute ... #LiverFailure #Hepatic
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
RBCs, muscle, liver ... lung injuries Hepatic ... Injury: • Early acute ... hepatitis • Acute ... Idiosyncratic LDH Elevation
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