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diagnosis hepatology differential lfts transaminitis hepatitis injury abnormal causes elevated enzymes hepatocellular laboratory acute aflp alkaline chemistry cholestatic comparison dehydrogenase
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Liver Function Test ... (LFTs) Elevation ... specific for the liver ... #FunctionTest # ... LFTs #Elevation
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
phos/ULN ALP) ... Bilirubin - +/- elevation ... replaced by non-hepatic ... or amyloid: • Elevation ... Enzyme Elevation
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... Injury: • Hepatic ... Venoocclusive disease • Hepatic ... • Pregnancy: HELLP ... Enzyme Elevation
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
Diagnosis Algorithm ... disturbance (obstructed liver ... Highest • Bone • Liver ... Hepatic source: ... #Diagnosis #Algorithm
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
to 10-20-fold elevation ... , no necrosis HELLP ... to 10-20-fold elevation ... diagnosis #icp #HELLP ... #AFLP
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Liver Enzymes (LFTs ... and Cholestatic Liver ... Hepatocellular Liver ... elevation > Alk ... specific for hepatic
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Differential Diagnosis Algorithm ... or AST > ALP): ... , HELLP • Moderate ... Cholestatic Pattern (ALP
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute Liver ... biliary obstruction, HELLP ... Vasculature • Hepatic ... Congestion/CHF • Hepatic ... Causes #Acute #algorithm
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... Differential Diagnosis Algorithm ... Severe ALT > 15x ... , HELLP Moderate ... Differential #Diagnosis #Algorithm
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
tests algorithm ... box indicates all ... magnitude of enzyme elevation ... ALP, alkaline phosphatase ... LFTs #Abnormal #Algorithm
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