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ebm visualabstract diagnosis management pocus ultrasound nejm differential clinical nephrology algorithm cardiology causes criticalcare gallbladder treatment comparison table pulmonary pathology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Henoch-SchonIein Purpura Anti-GBM ... to Kidney: Anti-GBM ... involvement: Anti-GBM
Kidney Biopsy - Diagnosis Algorithms 1) Normal Glomerulus by LM 2) Glomerular Crescents 3) Double Contours of GBM 4) Endocapillary
Double Contours of GBM
Approach to managing Glomerulonephritis (GN) in children. ANCA, antineutrophil cytoplasmic antibodies; c-ANCA, cytoplasmic antineutrophil cytoplasmic antibodies;
cytoplasmic antibodies; GBM
Spectrum of Glomerular Diseases Nephrotic - Mechanism: • Injury to podocytes • Changed architecture: Scanning. Deposition of
• Breaks in GBM
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis 90%: -
Vasculitis - Anti-GBM ... Positive (ANCA + anti-GBM
Rapidly Progressive Glomerulonephritis (RPGN) - Loss of kidney function over a short period of tirne
Basement Membrane (GBM ... Linear, ribbon-like GBM
Stage III Glomerulonephritis on Electron Microscopy This image shows acellular scanning EM from a biopsy with membranous
more extensive GBM ... surface of reticular GBM ... #MGN #stage3 #GBM
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 Glomerulonephritis - Differential Diagnosis Framework ANCA: • C-ANCA: GPA (Wegener's) • P-ANCA: Microscopic Polyangiitis, Eosinophilic GPA (Churg
Strauss) Anti-GBM
Causes of acute kidney injury (AKI). AKI is classified into pre-renal, renal, and post-renal causes. Renal
GBM, Glomerular
Causes of Hematuria - Differential Diagnosis Algorithm Red blood cells on urine microscopy. Must exclude false positives
nephropathy • Thin GBM ... ) • Anti-GBM
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