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hematology causes algorithm oncology signs treatment neurology hemolytic sle syndrome thrombocytopenia cardiology erythematosus pulmonary syndromes systemic aplastic arthritis bruising classification
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Complement: Post-strep GN ... , Lupus Nephritis ... #differential # ... diagnosis #algorithm ... #rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Autoimmunity: • -MM/WM: Vasculitis ... (-) hemolytic anemia ... to cold IgG • Lupus ... #Monoclonal #Differential ... #Diagnosis #Oncology
Seronegative Inflammatory Arthritis - Differential Diagnosis • Seronegative Rheumatoid Arthritis • Infectious Arthritis: Viral, Bacterial,
Inflammatory Arthritis - Differential ... Diagnosis • Seronegative ... Disease: Systemic Lupus ... Erythematous, Systemic Vasculitis ... #Diagnosis #rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Features of Systemic Lupus ... Butterfly rash, Vasculitis ... ) Blood (75%): Anemia ... erythematosus #signs #symptoms ... #diagnosis #rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
- Hemolytic anemia ... Diagnosis and Lupus ... autoantibodies #signs #symptoms ... #mimickers #differential ... #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
rapidly progressing GN ... such as systemic lupus ... Presentation - Systemic Symptoms ... differential #diagnosis ... #rheumatology #
Hypertension and Altered Mental Status (AMS) - Differential Diagnosis Framework Hypertension: • Hypertensive emergency • Hypertensive encephalopathy
Status (AMS) - Differential ... Diagnosis Framework ... Renal: • Acute GN ... Autoimmune: • Vasculitis ... • Lupus • Polyarteritis
Diagnosis and management of Polyarteritis Nodosa (PAN) Chapel Hill 2012 definition: Necrotizing vasculitis ofmedium or small arteries
Diagnosis and management ... Necrotizing vasculitis ... PolyarteritisNodosa #Rheumatology ... #Diagnosis #Management ... #Vasculitis #Differential
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... Differential Diagnosis ... Presentation: Systemic Symptoms ... • Progressive symptoms ... Diagnosis #Rheumatology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Pancytopenia - Differential ... Diagnosis Congenital ... deficiency • Fanconi’s anemia ... Diseases: • Systemic lupus ... #Diagnosis #Hematology
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