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diagnosis differential management druginduced thrombocytopenia activation anemia causes classification comparison erythematosus glomerulonephritis hemolytic macrophage monoclonal oncology paraproteinemias platelets polycythemia progressive
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Lupus (DIL): ... myalgia, serositis, Kidney ... , SCLE-DIL (terbinafine ... • Immunologic Workup ... #table #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Complement: Post-strep GN ... , Lupus Nephritis ... • Limited to Kidney ... Glomerulonephritis #Vasculitis ... #rheumatology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Autoimmune • ITP • SLE ... Non-lmmune: • HELLP Syndrome ... • TTP/HUS • DIC ... • Vasculitis ... #Causes #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... for workup, including ... , Vasculitides, ... Kawasaki, Nephrotic syndrome ... #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Heart, lung, and kidney ... SJIA], systemic lupus ... erythematosus [SLE ... Diagnosis #Management #Hematology ... #Rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Non-autoimmune rheumatologic ... C4) • ds-DNA: Kidney ... • Kidney biopsy ... Erythematosus #Diagnosis #Rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
myopathy • Anti MAG ... Autoimmunity: • -MM/WM: Vasculitis ... Hypergammaglobulinemic macular Vasculitis ... to cold IgG • Lupus ... Paraproteinemias #Hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
rapidly progressing GN ... inflammation Others: • Lupus ... systemic lupus ... , and SLE) • Urinalysis ... differential #diagnosis #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
SLE, atherosclerotic ... musculoskeletal systems • Kidneys ... • Behcet syndrome ... • Cogan syndrome ... Differential #Diagnosis #Rheumatology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Differential Diagnosis Algorithm ... genotypes): SS, SC, SE ... thrombocytopenia - DIC ... cardiac valve, vasculitis ... #workup #hematology
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