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differential hematology cerebritis diffuse erythematosus glomerulonephritis lad lymphadenopathy monoclonal neurology paraproteinemias progressive rapidly rpgn sjogrens sle syndrome systemic treatment vasculitis
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Scleromyxedema (CNS ... to cold IgG • Lupus ... Paraproteinemias #Hematology ... #Differential #Diagnosis ... #Oncology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... Algorithm Reactive ... • Systemic Lupus ... #Algorithm #Causes ... #Hematology #Oncology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... autoantibodies that will cause ... permeability Diagnosis ... #neurology #rheumatology ... #management #treatment
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... Complement: Post-strep GN ... , Lupus Nephritis ... #differential #diagnosis ... #algorithm #rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... • 8%-27% for CNS ... Membranoproliferative GN ... Sjogrens #Syndrome #Rheumatology ... #Diagnosis #Management
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