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diagnosis differential vasculitis classification hydroxychloroquine management pharmacology sle table adverseeffects algorithm benefits cryoglobulinemia cryoglobulins druginduced glomerulonephritis levels measurement monoclonal oncology
Hydroxychloroquine Serum Measurement in SLE • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
half-life = 40 days ([HCQI ... • Special cases ... Hydroxychloroquine #HCQ ... Measurement #SLE #rheumatology ... pharmacology #levels #lupus
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... Complement: Post-strep GN ... , Lupus Nephritis ... diagnosis #algorithm #rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Zone Lymphoma (HCV ... Immunotactoid GN ... -C3 GN • Cast ... to cold IgG • Lupus ... Paraproteinemias #Hematology
Hydroxychloroquine - Risks and Benefits in Lupus Benefits: ↓ Disease activity, ↓ Flare, ↓ Damage, ↓ Corticosteroid dose,
and Benefits in Lupus ... rare with ~100 cases ... Hydroxychloroquine #hcq ... Risks #Benefits #Lupus ... #sideeffects #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Drug Induced Lupus ... cases, drug-dependent ... Discontinuation of causal ... #sle #comparison ... #table #rheumatology
TRALI vs TACO - Transfusion Reactions TRALI: • Epidemiology: 0.1% of transfused patientsl • Risk factors: Critical
transfusion • Criteria ... : ARDS Berlin Criteria ... without other cause ... Transfusion #Reactions #hematology ... #diagnosis #comparison
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... • Infections: HCV ... (e.g. systemic lupus ... classification #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
rapidly progressing GN ... tract, and often causes ... such as systemic lupus ... • HIV • HBV HCV ... differential #diagnosis #rheumatology
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