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diagnosis management classification differential vasculitis algorithm ana anca antibody antineutrophil antinuclear diseases druginduced erythematosus eularacr glomerulonephritis polychondritis progressive rapidly relapsing
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
Classification Criteria ... Highly specific antibodies ... Classification #Criteria ... #SLE #Systemic ... #diagnosis #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... Complement: Post-strep GN ... , Lupus Nephritis ... Purpura Anti-GBM antibodies ... diagnosis #algorithm #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
vs SLE Drug Induced ... cases, drug-dependent ... Discontinuation of causal ... #sle #comparison ... #table #rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antineutrophil cytoplasmic antibodies ... ) • Systemic lupus ... in drug-induced SLE ... Antineutrophil #antibodies ... #diagnosis #rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... Hypocomplementemia • Can cause ... Membranoproliferative GN ... Nephrogenic DI Hematologic ... Sjogrens #Syndrome #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
rapidly progressing GN ... tract, and often causes ... C-ANCA) pattern: antibodies ... vasculitis, and SLE ... differential #diagnosis #rheumatology
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
and fatigue Criteria ... hearing loss, nausea ... such as: • SLE ... Anti-Matrilin-1 Ab ○ Antibodies ... Polychondritis #rheumatology
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