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diagnosis differential erythematosus hematology nephrology sle systemic treatment crisis eularacr hemophagocytic hlh hodgkins lymphohistiocytosis lymphoma macrophage mas myelitis nephritis neurology
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... Criteria for Systemic ... low C4, Low C3 and ... #Criteria #SLE ... Erythematosus #diagnosis #rheumatology
Management of Lupus Nephritis Lupus nephritis (LN) in 10 to 40% of SLE Hallmark = proteinuria 20.5 g/g
Management of Lupus ... Nephritis Lupus ... severity (ISN/RPS classification ... by 12 months Classification ... #rheumatology #
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... SJIA], systemic lupus ... Histopathologic criteria ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Skin Disease Classification ... Non-autoimmune rheumatologic ... antibodies • (-) ANA ... Chronic B-cell activation ... Erythematosus #Diagnosis #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... IFN-y) → Excessive activation ... Infections+++: Virus ... Lymphohistiocytosis #diagnosis #management ... treatment #summary #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
rapidly progressing GN ... inflammation Others: • Lupus ... such as systemic lupus ... differential #diagnosis #rheumatology ... #classification
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
-95% of cases) Classification ... Arbor criteria ... lymphoma #diagnosis #classification ... #hematology #oncology ... #management
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
• Excessive activation ... Diagnostic Criteria ... zoster, West Nile virus ... Herpes simplex virus ... Myelitis #diagnosis #management
Scleroderma Renal Crisis (SRC) Clinical Presentation of Scleroderma Renal Crisis: 1) Acute kidney injury 2) Abrupt onset of hypertension 3)
endothelial cell activation ... of arteries Management ... confirm diagnosis and ... . pauci-immune GN ... Renal #Crisis #rheumatology
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