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diagnosis differential vasculitis allergy erythematosus hypersensitivity reactions rpgn sle systemic table algorithm champs clinicopathology comparison complement cryoglobulinemia cryoglobulins eularacr hematology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Rapidly Progressive Glomerulonephritis ... Complement: Post-strep GN ... , Lupus Nephritis ... Kidney: Anti-GBM Glomerulonephritis ... diagnosis #algorithm #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN) - Loss of kidney function over a short period of tirne
Rapidly Progressive Glomerulonephritis ... IgA nephropathy, lupus ... post-infectious GN ... autoAb against type ... #RPGN #Classification
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
, type 1 (50%-80% ... ), type II (80-90% ... S - Systemic Lupus ... Ann Marie Kumfer ... #differential #hematology
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... Criteria for Systemic ... low C4, Low C3 and ... #Criteria #SLE ... Erythematosus #diagnosis #rheumatology
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
Type I - lgE - ... Type Ill - IgG and ... Post-streptococcal glomerulonephritis ... systemic lupus ... #Classification
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Skin ulcers - Glomerulonephritis ... Types: • Type ... (e.g. systemic lupus ... #classification ... #rheumatology #
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
Summary table of types ... Type 1 - Mediators ... Post-streptococcal glomerulonephritis ... , Systemic lupus ... allergy #table #classification
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
rapidly progressing GN ... inflammation Others: • Lupus ... such as systemic lupus ... differential #diagnosis #rheumatology ... #classification
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Skin Disease Classification ... Non-autoimmune rheumatologic ... Kikuchi disease • Type-I ... Erythematosus #Diagnosis #Rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
IV RTA, TYPE I ... nephritis • Distal (Type ... acidosis • NAGMA • Glomerulonephritis ... Membranoproliferative GN ... Sjogrens #Syndrome #Rheumatology
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