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diagnosis differential classification hematology management syndrome allergy antinuclear erythematosus hypersensitivity oncology patterns reactions sle table types vasculitis aortitis autoantibodies autoimmune
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
Associated Rheumatic Diseases ... Juvenile Idiopathic Arthritis ... #Antinuclear #Antibodies ... #ANA #patterns ... #rheumatology #diagnosis
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Antibody refers to antibodies ... assay (IFA) is the main ... : Lupus (SLE), Systemic ... #rheumatology #diagnosis
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... • Systemic lupus ... • Fever is the main ... Diagnosis #Management #Hematology ... #Rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... Manifestations: - Arthritis ... SLE-Related Auto-Antibodies ... : - ANA 95-100% ... #differential #rheumatology
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
Polyarteritis Nodosa (PAN ... ), ANCA associated ... (RA), Systemic ... lupus erythematosus ... Differential #Diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Non-autoimmune rheumatologic ... : • Joint pain ... 1, SCL-70, RNP antibodies ... Chronic B-cell activation
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Congenital Diseases ... Inflammatory and ... : • Systemic lupus ... • Epstein-Barr virus ... Differential #Diagnosis #Hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
rapidly progressing GN ... Others: • Lupus ... LFT • ESR • ANA ... ) pattern: antibodies ... differential #diagnosis #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
GCA (Giant Cell Arteritis ... tract: Abdominal pain ... involvement, abdominal pain ... and GN Anti-GBM ... Differential #Diagnosis #Rheumatology
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
Allergen-specific lgE antibodies ... - Local and systemic ... during hemolytic disease ... glomerulonephritis, rheumatoid arthritis ... , and systemic lupus
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