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diagnosis classification management syndrome allergy differential hematology hypersensitivity reactions table ana antinuclear comparison erythematosus hemeonc hemophagocytic hlh laboratory lymphohistiocytosis macrophage
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Antibody refers to antibodies ... assay (IFA) is the main ... : Lupus (SLE), Systemic ... ANA #patterns #rheumatology
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
Allergen-specific lgE antibodies ... - Local and systemic ... during hemolytic disease ... glomerulonephritis, rheumatoid arthritis ... , and systemic lupus
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... • Systemic lupus ... • Fever is the main ... Diagnosis #Management #Hematology ... #Rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Non-autoimmune rheumatologic ... • Type-I Interferonopathies ... : • Joint pain ... Chronic B-cell activation
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
Action: IgG/lgM antibodies ... to complement activation ... reaction, Haemolytic disease ... glomerulonephritis, Systemic ... lupus erythematosus
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
rapidly progressing GN ... inflammation Others: • Lupus ... lupus erythematosus ... C-ANCA) pattern: antibodies ... differential #diagnosis #rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
IV RTA, TYPE I ... Central nervous system ... Membranoproliferative GN ... Arthralgia and Arthritis ... Sjogrens #Syndrome #Rheumatology
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
disease. ... Inflammation and pain ... such as certain types ... ’s syndrome - Lupus ... Syndrome #diagnosis #dermatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
affected joint • Systemic ... lupus erythematosus ... double-stranded DNA antibodies ... Tests for All Types ... , and low back pain
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
of the immune system ... Types of HLH • ... ▪ Autoimmune diseases ... inhibitors, anti-IFN-γ antibodies ... Diagnosis #Management #Hematology
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