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diagnosis differential sle systemic hematology symptoms vasculitis activation antibodies antinuclear autoantibodies causes classification disease isolated laboratory macrophage management mas mimickers
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
of hip (rare), Arthritis ... lesions Abdominal pain ... Glomerulonephritis Myositis ... #signs #symptoms ... #diagnosis #rheumatology
Causes of Isolated Neutropenia - Differential Diagnosis Algorithm Congenital Medications • Anticonvulsants • Antibiotics • Antithyroid • Antihypertensive
• Epstein-Barr Virus ... Destruction • Systemic Lupus ... Erythematosus ... • Rheumatoid Arthritis ... #Causes #Hematology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... Manifestations: - Arthritis ... anemia 4% - Myositis ... Auto-Antibodies: - ANA ... autoantibodies #signs
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
assay (IFA) is the main ... erythematosus ( ... erythematosus ( ... Sjögren Syndrome, Myositis ... #patterns #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Non-autoimmune rheumatologic ... : • Joint pain ... • Transverse Myelitis ... antibodies • (-) ANA ... #Diagnosis #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
rapidly progressing GN ... erythematosus, ... purpura: strong sign ... LFT • ESR • ANA ... differential #diagnosis #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
erythematosus ... • Fever is the main ... erythematosus [ ... Diagnosis #Management #Hematology ... #Rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
purpura: Strong sign ... ischemia • Skin: Erythematous ... tract: Abdominal pain ... and GN Anti-GBM ... Differential #Diagnosis #Rheumatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... joint • Systemic lupus ... erythematosus ( ... level to exclude myositis ... low back pain)
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