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diagnosis differential erythematosus systemic ana joint management patterns symptoms vasculitis workup approach autoantibodies classification disease laboratory mimickers monoarthritis monoarticular myelitis
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
erythematosus (SLE ... Juvenile Idiopathic Arthritis ... Kumfer @AnnKumfer #Antinuclear ... #Antibodies #ANA ... #patterns #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Antibody refers to antibodies ... assay (IFA) is the main ... Kumfer @AnnKumfer #Antinuclear ... #patterns #rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Manifestations: - Arthritis ... Auto-Antibodies ... Lupusreference #SLE ... autoantibodies #signs ... #differential #rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
(SLE) General: ... of hip (rare), Arthritis ... lesions Abdominal pain ... erythematosus #signs ... symptoms #diagnosis #rheumatology
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
noninflammatory Signs ... • SLE • Psoriatic ... Symmetrical: • RA • SLE ... #Diagnosis #MSK ... #rheumatology #
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Non-autoimmune rheumatologic ... : • Joint pain ... 1, SCL-70, RNP antibodies ... anticardiolipin antibodies
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... joint • Systemic lupus ... ) - Antinuclear ... double-stranded DNA antibodies ... , and low back pain
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
rapidly progressing GN ... purpura: strong sign ... C-ANCA) pattern: antibodies ... vasculitis, and SLE ... differential #diagnosis #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
diseases, such as SLE ... purpura: Strong sign ... tract: Abdominal pain ... involvement, abdominal pain ... Differential #Diagnosis #Rheumatology
Approach to Joint Pain - Diagnostic Framework 1) Chronicity 2) Inflammatory vs Non-Inflammatory 3) Number of Joints Involved 1) Chronicity:
Approach to Joint Pain ... spondyloarthropathies, lupus ... Chronic = RA, SLE ... #Joint #Pain #MSK ... #rheumatology #
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