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differential classification management algorithm cryoglobulinemia cryoglobulins erythematosus myelitis neurology progressive rapidly signs sjogrens symptoms syndrome systemic transverse types vasculitides
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Complement: Post-strep GN ... , Lupus Nephritis ... #Vasculitis #differential ... #diagnosis #algorithm ... #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN) - Loss of kidney function over a short period of tirne
(RPGN) - Loss ... IgA nephropathy, lupus ... post-infectious GN ... #Differential #Diagnosis ... #Nephrology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
rapidly progressing GN ... inflammation Others: • Lupus ... such as systemic lupus ... , and SLE) • Urinalysis ... #rheumatology #
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
(SLE) General: ... Butterfly rash, Vasculitis ... disease (30%): Glomerulonephritis ... signs #symptoms #diagnosis ... #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Diagnosis Framework ... Differential Diagnosis ... diseases, such as SLE ... (Glomerulonephritis ... #Rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Skin ulcers - Glomerulonephritis ... Labs/Diagnosis: ... (e.g. systemic lupus ... erythematosus (SLE ... classification #rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... ) • Cutaneous vasculitis ... acidosis • NAGMA • Glomerulonephritis ... Membranoproliferative GN ... Sjogrens #Syndrome #Rheumatology
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
than 2/3 of the cross-sectional ... Evaluate for NMO, SLE ... Disorders: - SLE ... - Sjogren - Vasculitis ... #management #neurology
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