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diagnosis classification vasculitis differential management syndrome acute allergy ana anca antineutrophil antinuclear arthritis comparison cryoglobulinemia cryoglobulins disease glomerulonephritis hematology hemeonc
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antineutrophil cytoplasmic antibodies ... ) • Systemic lupus ... drug-induced SLE) • Systemic ... Antineutrophil #antibodies ... #diagnosis #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... Complement: Post-strep GN ... , Lupus Nephritis ... Purpura Anti-GBM antibodies ... #rheumatology
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
Allergen-specific lgE causes ... Action: IgG/lgM antibodies ... reaction, Haemolytic disease ... glomerulonephritis, Systemic ... lupus erythematosus
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... • Autoimmune diseases ... Antineutrophil cytoplasmic antibody ... lupus erythematosus ... classification #rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... TYPE IV RTA, TYPE ... Central nervous system ... Membranoproliferative GN ... Sjogrens #Syndrome #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
rapidly progressing GN ... tract, and often causes ... purpura: strong sign ... C-ANCA) pattern: antibodies ... differential #diagnosis #rheumatology
Acute Retroviral Syndrome Acute Retroviral Syndrome is the symptomatic presentation of acute human immunodeficiency virus infection •
mononucleosis/flu type ... Central nervous system ... Detects both HIV antibody ... HIV-1 or HIV-2 antibodies ... ART to slow HIV disease
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... affected joint • Systemic ... lupus erythematosus ... double-stranded DNA antibodies ... Tests for All Types
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
hyperinflammatory syndrome caused ... of the immune system ... Types of HLH • ... ▪ Autoimmune diseases ... Presentation • Common Signs
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