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diagnosis differential vasculitis management syndrome acute anca antineutrophil antinuclear antinxp2 antinxp2dm antiphospholipid apls autoimmune classification dermatology dermatomyositis diseases glomerulonephritis hematology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... Complement: Post-strep GN ... , Lupus Nephritis ... Purpura Anti-GBM antibodies ... #rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... Antibody) and ANCA ... ) • Systemic lupus ... drug-induced SLE) • Systemic ... #rheumatology #
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
proteinuria, Rapidly progressing ... purpura: Strong sign ... (rapidly progressive ... often causes arthritis ... Differential #Diagnosis #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
proteinuria, rapidly progressing ... GN • New pulmonary ... often causes arthritis ... purpura: strong sign ... ) pattern: antibodies
Antiphospholipid Syndrome (APLS) Testing - Hypercoagulable Workup Algorithm INDICATIONS FOR TESTING: • Vascular thrombosis
Hypercoagulable Workup Algorithm ... chromosomal causes ... excluded Testing: • Lupus ... Hypercoagulable #Workup #Algorithm ... #diagnosis #hematology
Acute Retroviral Syndrome Acute Retroviral Syndrome is the symptomatic presentation of acute human immunodeficiency virus infection •
Central nervous system ... Detects both HIV antibody ... HIV-1 or HIV-2 antibodies ... IgM-sensitive HIV-1 antibody ... slow HIV disease progression
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
• Bilateral signs ... IgG index • Progression ... sclerosis, NMOSD, MOG antibody ... glycoprotein (MOG) antibody ... Antiamphiphysin antibodies
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
RP-ILD), dermato-rheumatologic ... Gottron sign) ... • Shawl sign • ... • Conduction system ... statins - probably caused
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
• Antibodies targeting ... Manifestations: • Progressive ... Muscle atrophy may cause ... levels • NXP-2 antibody ... diagnosis #management #rheumatology
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