9 results
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
Rapidly Progressive ... Complement: Post-strep GN ... , Lupus Nephritis ... StanfordChiefs #RPGN #Rapidly ... diagnosis #algorithm #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN) 
 - Loss of kidney function over a short period of tirne
Rapidly Progressive ... IgA nephropathy, lupus ... post-infectious GN ... autoAb against type ... #RPGN #Classification
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
Type Ill - IgG and ... Post-streptococcal glomerulonephritis ... systemic lupus ... #Classification ... Diagnosis #Reactions #Table
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
findings (ANA, ... Skin Disease Classification ... Non-autoimmune rheumatologic ... Kikuchi disease • Type-I ... Erythematosus #Diagnosis #Rheumatology
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
Summary table of ... Post-streptococcal glomerulonephritis ... , Systemic lupus ... #allergy #table ... #classification
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
, proteinuria, rapidly ... progressing GN ... LFT • ESR • ANA ... differential #diagnosis #rheumatology ... #classification
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Skin ulcers - Glomerulonephritis ... Types: • Type ... (e.g. systemic lupus ... #classification ... #rheumatology #
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
IV RTA, TYPE I ... • Interstitial nephritis ... acidosis • NAGMA • Glomerulonephritis ... Membranoproliferative GN ... Sjogrens #Syndrome #Rheumatology
Monoclonal Gammopathy of Renal Significance (MGRS)

MGRS
• MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
Clinical Clues: • Nephrotic-range ... proteinuria with rapid ... guide subtype classification ... vasculitis Types ... immunotactoid GN