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diagnosis differential vasculitis allergy erythematosus hypersensitivity reactions rpgn systemic algorithm antinuclear autoantibodies champs comparison complement cryoglobulinemia cryoglobulins hematology hypocomplementemia low
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Rapidly Progressive Glomerulonephritis ... Complement: Post-strep GN ... , Lupus Nephritis ... Kidney: Anti-GBM Glomerulonephritis ... diagnosis #algorithm #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN) - Loss of kidney function over a short period of tirne
IgA nephropathy, lupus ... nephritis, cryoglobulinemia ... post-infectious GN ... autoAb against type ... #RPGN #Classification
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
autoimmune (RA, Sjogren's ... , type 1 (50%-80% ... S - Systemic Lupus ... Ann Marie Kumfer ... #differential #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
findings (ANA, ... Skin Disease Classification ... dermatomyositis, Sjogren ... Non-autoimmune rheumatologic ... Kikuchi disease • Type-I
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
lupus nephritis ... and Sjogren Anti-SSB ... and neonatal lupus ... erythematosus #diagnosis #rheumatology ... #table #ANA
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Skin ulcers - Glomerulonephritis ... RA - 5 to 20% Sjögren's ... (e.g. systemic lupus ... #classification ... #rheumatology #
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
Type Ill - IgG and ... Post-streptococcal glomerulonephritis ... systemic lupus ... #Classification ... Diagnosis #Reactions #Table
Classification of Vasculitis Vasculitis of large vessels - Arteritis temporalis (giant-cell arteritis) - Takayasu
Classification of ... - systemic lupus ... purpura-arthralgia-nephritis ... disease - Sjögren ... Vessels #Diagnosis #Rheumatology
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
Summary table of ... Post-streptococcal glomerulonephritis ... , Systemic lupus ... #allergy #table ... #classification
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... • Interstitial nephritis ... acidosis • NAGMA • Glomerulonephritis ... Membranoproliferative GN ... #Syndrome #Rheumatology
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