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diagnosis differential vasculitis allergy erythematosus hypersensitivity reactions rpgn systemic algorithm antinuclear autoantibodies champs comparison complement cryoglobulinemia cryoglobulins hematology hypocomplementemia low
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Rapidly Progressive Glomerulonephritis ... Complement: Post-strep GN ... , Lupus Nephritis ... Kidney: Anti-GBM Glomerulonephritis ... diagnosis #algorithm #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN) - Loss of kidney function over a short period of tirne
IgA nephropathy, lupus ... nephritis, cryoglobulinemia ... post-infectious GN ... autoAb against type ... #RPGN #Classification
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
antiphospholipid syndrome ... , type 1 (50%-80% ... S - Systemic Lupus ... Ann Marie Kumfer ... #differential #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
findings (ANA, ... Skin Disease Classification ... Non-autoimmune rheumatologic ... Kikuchi disease • Type-I ... Erythematosus #Diagnosis #Rheumatology
Classification of Vasculitis Vasculitis of large vessels - Arteritis temporalis (giant-cell arteritis) - Takayasu
Classification of ... - systemic lupus ... purpura-arthralgia-nephritis ... dermatomyositis #Size #Classification ... Vessels #Diagnosis #Rheumatology
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
Type Ill - IgG and ... Post-streptococcal glomerulonephritis ... systemic lupus ... #Classification ... Diagnosis #Reactions #Table
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Skin ulcers - Glomerulonephritis ... Types: • Type ... (e.g. systemic lupus ... #classification ... #rheumatology #
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
Summary table of ... Post-streptococcal glomerulonephritis ... , Systemic lupus ... #allergy #table ... #classification
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
rapidly progressing GN ... such as systemic lupus ... LFT • ESR • ANA ... differential #diagnosis #rheumatology ... #classification
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Systemic lupus ... lupus nephritis ... SLE-SSc-AlM overlap syndromes ... erythematosus #diagnosis #rheumatology ... #table #ANA
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