62 results
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Phosphatase Of Clinical ... • Pernicious anemia ... /B12 deficiency ... collection with EDTA Pathophysiology ... ) - Waddling gait
Criss-Cross Gait on Physical Exam 

Seen in Glucose Transporter type 1 Deficiency Syndrome

#CrissCross #Criss #Cross #Gait
Criss-Cross Gait ... Transporter type 1 Deficiency ... #Criss #Cross #Gait ... #PhysicalExam #clinical ... neurology #GLUT1 #deficiency
Wernicke Encephalopathy - Acute Thiamine (B1) Deficiency 
Clinical Diagnosis - Caine Criteria (2 out of 4):
Thiamine (B1) Deficiency ... Clinical Diagnosis ... dysfunction - Dietary deficiency ... dysfunction and gait ... #Thiamine #B1 #Deficiency
Elliptocyte - 
Note the shape of these appropriately named erythrocytes.
In addition to hereditary elliptocytosis, elliptocytes can
megaloblastic anemia ... myelophthisic anemia ... and severe iron deficiency ... anemia. ... #Clinical #Path
Peripheral Blood Smear Analysis
Hypochromia
Megaloblastic Anemia
Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS)
Microspherocytes: Autoimmune hemolytic anemia
Sickled red
Megaloblastic Anemia ... Autoimmune hemolytic anemia ... Bite cells: G6PD deficiency ... interpretation #clinical ... #anemia
Wernicke's Encephalopathy vs Korsakoff Syndrome - Thiamine Deficiency

Wernicke's encephalopathy is a neurological condition due to longstanding
Syndrome - Thiamine Deficiency ... thiamine (vitamin B1) deficiency ... ataxia (broad-based gait ... and retrograde amnesia ... #B1 #thiamine #deficiency
Here is another peripheral blood smear demonstrating changes with iron deficiency anemia. Note the increased zone
changes with iron deficiency ... anemia. ... #Clinical #Path ... PeripheralBloodSmear #BloodSmear #Anemia
Clinically Important Vitamins and Vitamin Deficiency States
Fat-soluble Vitamins: 
 • Vitamin A - Xerophthalmia, night blindness,
Clinically Important ... Vitamins and Vitamin Deficiency ... E - Haemolytic anaemia ... Vitamin B12 - Anaemia ... #Vitamins #Deficiency
Vitamin B12 (Cobalamin) Deficiency
Etiology:
 • Vit B12 - aka cobalamin. Present in foods derived from animal
B12 (Cobalamin) Deficiency ... intrinsic factor, IF) Clinical ... wt loss • If anemia ... parasthesias, gait ... B12 #Cobalamin #Deficiency
Trendelenburg Gait: Pathogenesis and clinical findings

Skeletal Pathology of the Hip
 • Arthritis
 • Congenital hip dysplasia
Trendelenburg Gait ... Pathogenesis and clinical ... Trendelenburg Gait ... Trendelenburg #Gait ... #pathophysiology