14 results
Acromegaly 
Caused by over-secretion of growth hormone (GH) from the pituitary gland. 
The condition is rare
Acromegaly Caused ... (GH) from the pituitary ... gland. ... #Symptoms #Diagnosis ... #Endocrinology
Acromegaly - Diagnosis and Management Summary - GrepMed Handbook 

Clinical Presentation: 
 • Classic Acromegaly: frontal
Acromegaly - Diagnosis ... malignancy Pathophysiology ... • Pituitary ... #Endocrinology ... #Treatment #Pathophysiology
Multiple Endocrine Neoplasias (MEN syndromes) 

MEN I
• Hyperparathyroidism 
• Hypercalcemia 
• Possible ZE syndrome 
• Various
syndrome • Various Pituitary ... path • Acromegaly ... #Differential #Endocrinology ... Classification #Diagnosis
The principal endocrine 'axes' and glands. Parathyroid glands, adrenal zona glomerulosa and endocrine pancreas are not
controlled by the pituitary ... Endocrine #Axes #Endocrinology ... #Pathophysiology ... #Pathways #Diagnosis ... #Pituitary #Axis
Clinical Effects of Large and Small Pituitary Tumours
Local complications - Headache, Visual field defect, Disconnection hyperprolactinaemia,
Large and Small Pituitary ... infarction/expansion (pituitary ... Hypogonadism • Acromegaly ... Signs #Symptoms #Diagnosis ... #Endocrinology
Acromegaly Testing Algorithm
INDICATIONS FOR TESTING:
 • Adults – enlarged facial or acral features, abnormal musculoskeletal growth
Acromegaly Testing ... MRI to evaluate pituitary ... gland and consider ... Testing #Algorithm #diagnosis ... #endocrinology
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
- Giantism or acromegaly ... #FeedbackLoop #endocrinology ... #pathophysiology ... #pituitary
Sellar / Pituitary Mass - Differential Diagnosis Algorithm
Adenoma - Primary Anterior Pituitary
 - Secreting
Sellar / Pituitary ... - Differential Diagnosis ... Autoimmune • Giant ... #Differential #Diagnosis ... #Algorithm #endocrinology
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
clinical findings • Acromegaly ... share the same pathophysiology ... Overproduction #diagnosis ... signs #symptoms #endocrinology ... #pathophysiology
Primary vs Secondary Adrenal Insufficiency - Pathophysiology
Primary AI = adrenal glands themselves are the problem. This
Insufficiency - Pathophysiology ... Secondary AI = the pituitary ... gland is the culprit ... Insufficiency #Pathophysiology ... #endocrinology