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Differential diagnosis on HRCT
Most of our knowledge about imaging findings in interstitial lung disease comes from

there are four patterns ... : reticular, nodular ... low attenuation (table ... is reticular. ... presents as a reticular

Here are the most common examples of these four patterns on a chest x-ray (click image

of these four patterns ... consolidation - Multifocal ill-defined ... Interstitial - Reticular ... Consolidation #Patterns

Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns
Nuclear Patterns:
• Homogeneous pattern:
-

and Cytoplasmic Patterns ... Nuclear Patterns ... • Homogeneous pattern ... : • Reticular/ ... SLE, SjS, CTD-ILD

Whenever you see an area of increased density within the lung, it must be the result

of these four patterns ... or multifocal ill-defined ... fine or coarse reticular ... Consolidation #Patterns

Figure 3 HRCT-LUS correlation in normal lung, pulmonary congestion, rheumatoid lung disease, idiopathic pulmonary fibrosis.
Notes: (A)

artifact); (G) UIP pattern ... subpleural, basal reticular ... #Correlation #Table ... #ILD #Findings

Reticular pattern
1. Lymphangitic carcinomatosis: irregular septal thickening, usually focal or unilateral 50% adenopathy', known carcinoma.
2.

Reticular pattern ... HRCT #CTChest #Reticular ... #Pattern #Comparison ... #Table #RadiologyAssistant

Basic Interpretation
A structured approach to interpretation of HRCT involves the following questions:
What is the dominant HR-pattern:
reticular
nodular
high

the dominant HR-pattern ... : reticular nodular ... Interpretation #Algorithm ... #ILD #RadiologyAssistant

On the left a patient with DIP.
The HRCT shows diffuse areas of ground-glass density in the

and some mosaic pattern ... Reticular abnormalities ... DesquamativeInterstitialPneumonia #ILD

Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
•

purpura, livedo reticularis ... and bullous or vesicular ... - (C-ANCA) pattern ... - (P-ANCA) pattern ... #rheumatology #classification

Antinuclear Antibody Testing Cytoplasmic Patterns
Reticular/AMA:
• PBC, SSc, PBC/SSc OS, PBC/SjS OS
• AMA
Speckled:
•

Testing Cytoplasmic Patterns ... Reticular/AMA: ... SLE, SjS, CTD-ILD ... #Cytoplasmic #Patterns

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