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Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
Gitelman Syndrome ... cotransporter • Gitelman's ... ratio 0.5%) Differential ... Pseudo Bartter-Gitelman ... Magnesium #Gitelman
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm Volume Depleted 2° hyperaldosteronism • Low Urine Cl-: Vomiting, NGT
Metabolic Alkalosis - Differential ... Bartter Syndrome, Gitelman ... Metabolic #Alkalosis #Differential
Hypomagnesemia - Differential Diagnosis Renal Causes of Hypomagnesemia - Familial: Bartter syndrome and Gitelman syndrome, Isolated recessive hypomagnesemia,
Hypomagnesemia - Differential ... Bartter syndrome and Gitelman ... Hypomagnesemia #differential
Hypokalemia - Differential Diagnosis Algorithm Extra-renal Losses: • Normal Acid-Base: Low intake • Metabolic acidosis: Gl tract
Hypokalemia - Differential ... Bartter syndrome, Gitelman ... #Hypokalemia #Differential
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm Volume Depleted - 2° hyperaldosteronism • Low Urine Cl-: Vomiting,
Metabolic Alkalosis - Differential ... Bartter Syndrome, Gitelman ... Metabolic #Alkalosis #Differential
Causes of Metabolic Alkalosis - Differential Diagnosis Chloride depletion syndromes • Gastrointestinal losses -
Metabolic Alkalosis - Differential ... syndrome - Gitelman ... Metabolic #Alkalosis #Differential
Hypokalemia Differential Diagnosis Algorithm Low intake • poor oral intake Renal loss • Medication • Hypomagnesemia •
Hypokalemia Differential ... tubular acidosis • Gitelman's ... #Hypokalemia #Differential
Causes of Metabolic Alkalosis - Differential Diagnosis Algorithm Urine chloride < 20 mmol/l - Chloride responsive (Chloride
Metabolic Alkalosis - Differential ... Bartter's Syndrome, Gitelman's ... Alkalosis #Causes #Differential
Hypomagnesemia - Etiologies by Mechanism Decreased GI Uptake - Poor dietary intake (particularly common in alcoholics)
syndromes - Gitelman ... Hypomagnesemia #Differential
Metabolic Alkalosis - Differential Diagnosis Algorithm - Urinary Chloride • Cl- responsive metabolic alkalosis
Metabolic Alkalosis - Differential ... Bartter syndrome, Gitelman ... Metabolic #Alkalosis #Differential
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