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diagnosis differential nephrology aki algorithm causes renal rheumatology classification management workup ankylosingspondylitis antigbm basement blood complications dehydrogenase druginduced elevated extraarticular
Causes of acute kidney injury (AKI). AKI is classified into pre-renal, renal, and post-renal causes. Renal
kidney injury (AKI ... vascular supply; glomerular ... and interstitial disease ... GBM, Glomerular ... #Kidney #Injury
Acute Kidney Injury (AKI) - Differential Diagnosis Framework PRE-Renal AKI: • Hypovolemia • Congestion • Medications •
Acute Kidney Injury ... • Vascular • Glomerular ... Immune-complex disease ... , Anti-GBM • Tubular ... #Kidney #Injury
Acute Kidney Injury - Classification Prerenal: • Dehydration • Heart failure (a.k.a. cardiorenal syndrome) • Liver failure
Acute Kidney Injury ... - Small vessel vasculitis ... - TTP/HUS • Glomerular ... disease - Post-infectious ... #Kidney #Injury
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pulmonary Renal ... ANCA-positive vasculitis ... ANCA-negative vasculitis ... IgA-associated vasculitis ... sclerosis • Anti-Glomerular
Drug Induced Kidney Injury • Pre-Renal: NSAIDS, CNI, ACEI/ARB, IL-2 therapy, Diuretics CAR-T therapy • Osmotic
Drug Induced Kidney ... Injury • Pre-Renal ... Vitamin C • Glomerular ... Disease: Drug induced ... vasculitis, TMA
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
glomerulonephritis) • Anti-GBM ... - Skin, glomeruli ... (anti-C1q Vasculitis ... : glomerular ischemia ... purpura: strong sign
Anti-GIomeruIar Basement Membrane Disease (Goodpasture's Disease) What is it? A small vessel vasculitis with circulating antibodies directed
Anti-GIomeruIar ... A small vessel vasculitis ... directed against the glomerular ... following: Serum, Kidney ... diagnosis #nephrology #pulmonary
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
three primary pathophysiologic ... • Limited to Kidney ... With associated pulmonary ... Disease (Goodpasture's ... Glomerulonephritis #Vasculitis
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
Acute Kidney Injury ... clinical context and signs ... Glomerulonephritis / Vasculits ... , Anti-ds-DNA, C3 ... #Kidney #Injury
Hematuria - Differential Diagnosis Framework Gross Hematuria: Red/Dark urine • 1ml blood/liter urine can induce color change
or dipstick) Glomerular ... Immune mediated injury ... • Causes of Glomerular ... of glomerular hematuria ... Suggestive of glomerular
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