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differential algorithm management acute aki kidney proteinuria glomerulonephritis microscopy nephritic rhabdomyolysis rheumatology urology vasculitis acidosis associated atlas blood cancer comparison
Glomerular Diseases - Nephritic and Nephrotic Syndromes Nephritic syndrome—due to GBM disruption. Hypertension. t BUN and creatinine.
Glomerular Diseases ... Nephrotic Syndromes ... Nephritic syndrome—due ... RBC casts in urine ... #Nephrotic #Syndromes
Nephritic vs Nephrotic Syndrome Step 1: If the patient has hematuria and/or proteinuria, think about nephrotic/nephritic syndromes. Step
Syndrome Step ... /nephritic syndromes ... the patient have glomerular ... casts or dysmorphic ... #Syndrome #Comparison
Hematuria - Differential Diagnosis Framework Gross Hematuria: Red/Dark urine • 1ml blood/liter urine can induce color change
- Alport syndrome ... syndrome: • ... • Signs of glomerular ... RBC casts → Diagnostic ... #nephrology #renal
Atlas of Urine Microscopy Findings • Epithelial cells - Normal • Renal tubular cells - Acute
red - cells Non-glomerular ... Dysmorphic red cells - Glomerular ... glomerular disease ... renal disease ... #nephrology #casts
Causes of Hematuria - Differential Diagnosis Algorithm Red blood cells on urine microscopy. Must exclude false positives
Causes of Hematuria ... • Calculi Glomerular ... RBCs and/or RBC casts ... epithelial side of glomerular ... endothelial side of glomerular
Causes of Hematuria - Differential Diagnosis Renal: - Glomerular - IgA Nephropathy, Thin basement membrane, Alport syndrome,
Causes of Hematuria ... Renal: - Glomerular ... membrane, Alport syndrome ... - Interstitial nephritis ... #Diagnosis #Causes
Acute Kidney Injury - Classification Prerenal: • Dehydration • Heart failure (a.k.a. cardiorenal syndrome) • Liver failure
a.k.a. cardiorenal syndrome ... a.k.a. hepatorenal syndrome ... - TTP/HUS • Glomerular ... tubular necrosis (causes ... #diagnosis #nephrology
Algorithm - Approach to the differential diagnosis of the patient presenting with overt glomerular proteinuria. CMV
presenting with overt glomerular ... Cytomegalovirus; GBM = glomerular ... hemolytic-uremic syndrome ... cell/white cell casts ... #nephrotic #syndrome
Urinary Casts and Disease Associations Hyaline - May be nonspecific; seen in normal individuals or during severe
Urinary Casts and ... breakdown of cellular casts ... heme-granular casts ... syndrome ("Maltese ... 34t5DgJ #Urinary #Casts
Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
• Fanconi's syndrome ... • Drugs Glomerular ... sediment - WBC/RBC casts ... Minimal change disease ... #Proteinuria #Nephrology
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