14 results
SGLT2 Inhibitors - Pharmacology Summary
Mechanisms of Action: Inhibits SGLT2 (sodium/glucose cotransporter 2) in the proximal tubule,
- Pharmacology Summary ... mL/minute/1.73 m2 ... diabetic ketoacidosis ... #Pharmacology #Summary ... #DM2 #diabetes
Diabetes Medications Summary Table
Insulin
Lifestyle modifications
Metformin
Sulfonylureas
GLP-1 receptor agonists - ↓ major adverse CV events
TZDs
DPP-4 inhibitors
SGLT2 inhibitors -
Diabetes Medications ... Summary Table ... events TZDs DPP-4 inhibitors ... SGLT2 inhibitors ... endocrinology #dm2
Metformin Pharmacology Summary
Mechanisms of Action:
 • Suppresses gluconeogenesis by the liver
 • Increases insulin-mediated glucose utilization
Metformin Pharmacology Summary ... agent • Does not cause ... mL/minute/1.73 m2 ... #Pharmacology #Summary ... #DM2 #diabetes
Type 2 Diabetes - Screening, Diagnosis and Management Algorithm
Lifestyle  Modifications (Diet and Exercise) -> Start
Type 2 Diabetes ... relative with DM2 ... Hypertension, Overweight, Abdominal ... • Secondary Causes ... Management #algorithm #DM2
DPP-4 Inhibitors - Pharmacology Summary
Mechanisms of Action: Inhibits DPP-4 (dipeptidyl peptidase 4), which normally inactivates GLP-1
DPP-4 Inhibitors ... - Pharmacology Summary ... not definitively cause ... #Pharmacology #Summary ... #DM2 #diabetes
SGLT2 Inhibitors 
SGLT2 inhibitors are the newest class of anti-diabetic medications, with the first one (Canagliflozin)
SGLT2 Inhibitors ... class of anti-diabetic ... kidney), which causes ... #Medications #DM2 ... #Diabetes #Endocrinology
Diabetes Mellitus Type 2 Inpatient Medication Guide

Classes: Biguanide, Sulfonylurea, TZD, DPP-4 inhibitor, GLP-1 receptor agonist, SGLT2i,
Diabetes Mellitus ... Medication Guide Classes ... Sulfonylurea, TZD, DPP-4 inhibitor ... α-glucosidase inhibitor ... #Mellitus #DM2
GLP-1 Receptor Agonists - Pharmacology Summary
Mechanisms of Action: Stimulate glucose-dependent insulin release from the pancreas (GLP-1
- Pharmacology Summary ... e.g. diarrhea, nausea ... not definitively cause ... #Pharmacology #Summary ... #DM2 #diabetes
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
Poorly controlled DM ... NSAIDs • ACE Inhibitors ... (Uncontrolled diabetes ... differential #diagnosis #causes
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Drugs, Unknown cause ... Etoposide/VP16 (100 mg/m2 ... , ICU in case of ... Anti-IFN-y and JAK inhibitors ... management #treatment #summary