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clinical ultrasound diagnosis echocardiogram cardiology differential management pulmonary algorithm rheumatology a4c abdominal lung treatment effusion plax psax msk nephrology liver
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... Henoch-SchonIein Purpura Anti-GBM ... Limited to Kidney: Anti-GBM ... pulmonary involvement: Anti-GBM ... Disease (Goodpasture's
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
- SLE Anti-histone ... (AMA), Anti-sp100 ... - SLE Anti-SSA ... (Ro), Anti-SSB ( ... - Goodpasture's
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
polyangiitis) Anti-basement ... membrane: Goodpasture ... ANCA antibody, Anti-GBM ... FINDINGS: • AAV or Goodpasture's ... cause pulmonary
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
sclerosis • Anti-Glomerular ... Basement Membrane: Goodpasture's ... Disease-specific testing: anti-ANCA ... ab, anti-GBM ab ... , ANA, C3, C4, anti-CCP
Hemoptysis - Differential Diagnosis Framework Airways: • Bronchitis • Bronchiectasis • Malignancy: Primary bronchogenic CA, Endobronchial
Rheumatic/lmmune: Goodpastures ... Diagnosis #pulmonary #causes
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Anti-dsDNA (in 70% ... of cases) 2 ... Anti-Sm (Smith) ... Anti-histone (in ... seen in 30—70% of cases
Causes of Hemoptysis - Differential Diagnosis Algorithm Massive Hemoptysis (>I00 mL in 24 hours) • Malignancy •
Causes of Hemoptysis ... Erythematosus • Goodpasture's ... Diagnosis #Algorithm #Causes
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Causes of Thrombocytopenia ... practices that could cause ... ANA (e.g., SLE), anti-phospholipid ... disease), HBsAg/anti-HBc ... patients if the cause
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
10% of all lupus cases ... ) - Anti-ENA ... ) - Anti-histone ... Discontinuation of causal ... Positive in 60-80% of cases
Causes of Secondary Amenorrhea - Differential Diagnosis • Pregnancy • Endocrinopathies: PCOS, Hypothyroidism • HPA Dysfunction:
Causes of Secondary ... Dopamine antagonists, Anti-psychotics ... Differential #Diagnosis #Causes
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