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Anti-GIomeruIar Basement Membrane Disease (Goodpasture's Disease) What is it? A small vessel vasculitis with circulating antibodies directed
Anti-GIomeruIar ... Membrane Disease (Goodpasture's ... @PulmPEEPs #Anti ... Membrane #Disease #Goodpastures ... diagnosis #nephrology #pulmonary
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pulmonary Renal ... Presentation (Pulmonary ... Diagnosis for Pulmonary ... Basement Membrane: Goodpasture's ... ab, anti-GBM ab
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Henoch-SchonIein Purpura Anti-GBM ... Limited to Kidney: Anti-GBM ... With associated pulmonary ... involvement: Anti-GBM ... Disease (Goodpasture's
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
polyangiitis) Anti-basement ... membrane: Goodpasture ... ANCA antibody, Anti-GBM ... usually low in anti-GBM ... FINDINGS: • AAV or Goodpasture's
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
- SLE Anti-histone ... (AMA), Anti-sp100 ... - SLE Anti-SSA ... (Ro), Anti-SSB ( ... - Goodpasture's
Hemoptysis - Differential Diagnosis Framework Airways: • Bronchitis • Bronchiectasis • Malignancy: Primary bronchogenic CA, Endobronchial
Rheumatic/lmmune: Goodpastures ... syndrome, Idiopathic pulmonary ... Differential #Diagnosis #pulmonary
Systemic Sclerosis Associated Autoantibodies Anti-topoisomerase I (anti-Sc170): Diffuse skin disease, Pulmonary fibrosis Anti-centromere: Limited skin disease (~93-95%), Pulmonary
Autoantibodies Anti-topoisomerase ... I (anti-Sc170): ... skin disease, Pulmonary ... fibrosis Anti-centromere ... disease (~93-95%), Pulmonary
Causes of Hemoptysis - Differential Diagnosis Algorithm Massive Hemoptysis (>I00 mL in 24 hours) • Malignancy •
Bronchiectasis • Pulmonary ... Fungal Malignancy Pulmonary ... Erythematosus • Goodpasture's ... Vascular • Pulmonary ... Algorithm #Causes #Pulmonary
Biologic therapy for eosinophilic asthma • Mepolizumab (Nucala) • Anti-lL-5, 100 mg SQ q4
(Nucala) • Anti-lL ... Cinqair) • Anti-lL ... Fasenra) • Anti-lL ... Dupixent) • Anti-lL ... #pharmacology #pulmonary
Main types of autoimmune encephalitis in the ICU. Anti-NMDAR anti-N-methyl-d-aspartate receptor, ADEM acute disseminated encephalomyelitis, Anti-GFAP
Anti-NMDAR anti-N-methyl-d-aspartate ... anti-glial fibrillary ... anti-gamma aminobutyric ... anti-gamma aminobutyric ... anti-leucine-rich
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