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diagnosis differential management algorithm causes clinical treatment radiology pathophysiology neurology pulmonary cardiology hematology infections table rheumatology nephrology physicalexam signs gastroenterology
Anti-GIomeruIar Basement Membrane Disease (Goodpasture's Disease) What is it? A small vessel vasculitis with circulating antibodies directed
Basement Membrane Disease ... (Goodpasture's ... Disease) What ... #Goodpastures # ... AntiGBM #diagnosis
Classification of Vasculitis Vasculitis of large vessels - Arteritis temporalis (giant-cell arteritis) - Takayasu
nodosa - Buerger disease ... - Kawasaki disease ... and infectious diseases ... - serum disease ... hepatitis C - Goodpasture
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Autoantibodies and their Disease ... connective tissue disease ... (TTG) - Celiac disease ... Anti-GBM - Goodpasture's ... #Associations #diseases
Hemoptysis - Differential Diagnosis Framework Airways: • Bronchitis • Bronchiectasis • Malignancy: Primary bronchogenic CA, Endobronchial
Rheumatic/lmmune: Goodpastures ... syndrome • Valvular Disease
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
Mediators: lgE - Antigen ... Form: Soluble antigen ... Form: Cell-bound antigen ... reaction, Haemolytic disease ... complex - Antigen
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Peripheral edema, Disease-specific ... vasculitis, Behcet disease ... Basement Membrane: Goodpasture's ... Disease • Other ... dysmorphic RBCs) • Disease-specific
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
involvement: Anti-GBM Disease ... (Goodpasture's)
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
lgE - Soluble antigen ... IgM - Cell-bound antigen ... during hemolytic disease ... IgM - Soluble antigen ... - Antigen-antibody
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Anti-basement membrane: Goodpasture ... life-threatening diseases ... Inflammatory eye disease ... FINDINGS: • AAV or Goodpasture's
Hematuria in Post-Renal Transplant Patient Prevalence up to 12% in the postrenal transplant patient • Bacterial: Escherichia
, Busulfan • Disease ... Glomerulonephritis (Goodpasture's
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