14 results
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation ... Fever is the main clinical ... nervous system (CNS) dysfunction ... Histopathologic criteria ... Diagnosis #Management #Hematology
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
Risk factors: Critical ... sequestration and activation ... transfusion • Criteria ... : ARDS Berlin Criteria ... Transfusion #Reactions #hematology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Activation of CD8 ... IFN-y) → Excessive activation ... accumulation of clinical ... Assessment • Clinical ... , Hb), Hepatic dysfunction
Guide to systemic mastocytosis

Criteria for diagnosis: at least 1 major and 1 minor or 3 minor
mastocytosis Criteria ... minor or 3 minor criteria ... without organ dysfunction ... hemepath #pathology #algorithm ... #diagnosis #clinical
Abnormal liver function tests algorithm.
 This figure details the initial response to abnormal liver blood tests.
function tests algorithm ... /or suspicious clinical ... metabolic syndrome criteria ... LFTs #Abnormal #Algorithm ... #Hepatology #Liver
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... excessive macrophage activation ... genetic immune dysfunction ... management #treatment #hematology
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
bowel or bladder dysfunction ... • Excessive activation ... Transverse Myelitis - Clinical ... Autonomic Dysfunction ... Diagnostic Criteria
IGG-4 RELATED DISEASE

WHAT?
 • A chronic, immune-mediated fibroinflammatory disease with tumefactive infiltration of IgG4+ plasma cells
- Organ dysfunction ... specific) COMMON CLINICAL ... • Essential Criteria ... : Clinical/radiologic ... 2019 ACR/EULAR Criteria
Preoperative Risk Evaluation

Major Pre-Op Questions:
1. Does the patient have any modifiable risk factors that could be
Performance thorough ... event, follow ACC algorithm ... with valvular dysfunction ... or LV dysfunction ... Change in clinical
Hepatorenal Syndrome (HRS)

Definition:
• Functional, potentially reversible kidney impairment.
• Occurs in advanced liver disease: cirrhosis, severe alcoholic
sympathetic + ADH activation ... Diagnosis (Clinical ... Criteria): • ↑ ... Hepatorenal #Syndrome #Hepatology