9 results
Alzheimer’s Disease: Pathogenesis and Clinical Findings
Risk factor for Late Onset Alzheimer's (99% of cases):
 - Increasing
chromosome 21) Signs / Symptoms ... Aphasia, word-finding ... Executive planning dysfunction ... AlzheimersDisease #Dementia #pathophysiology ... diagnosis #signs #symptoms
Cauda Equina Syndrome
Causes:
 • Large lumbar degenerative disc herniation (central)
 • Severe lumbar spondylosis
 • Neoplasm
Equina Syndrome Causes ... spine Signs / Symptoms ... legs (numbness, tingling ... bladder/bowel dysfunction ... Syndrome #MSK #pathophysiology
Sarcoidosis - Diagnosis and Management Summary
Epidemiology
1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Diagnosis and Management ... survival is 93-95% Pathophysiology ... : 1) T-cell dysfunction ... are not caused ... incidental CXR finding
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... hepatocytes → Liver dysfunction ... postpartum): • Initial symptoms ... = nonspecific (nausea ... #pathophysiology
SEPSIS AND SEPTIC SHOCK

DEFINITION AND PATHOPHYSIOLOGY
 • Sepsis: Life-threatening organ dysfunction due to a dysregulated host
DEFINITION AND PATHOPHYSIOLOGY ... • Pathophysiology ... COMMON CAUSES + ... • Symptoms: Fever ... INITIAL MANAGEMENT
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
bowel or bladder dysfunction ... monophasic Pathophysiology ... Autonomic Dysfunction ... Bilateral signs and/or symptoms ... Myelitis #diagnosis #management
Amyotrophic Lateral Sclerosis (ALS) Summary
ALS: combination of the clinical examination finding of amyotrophy with the pathologic
the pathologic finding ... lateral sclerosis Pathophysiology ... - Causes progressive ... fasciculations Common Symptoms ... neurology #diagnosis #management
Posterior Reversible Encephalopathy Syndrome (PRES) Overview

Clinico-Radiological Syndrome, characterized by:
 • Headache
 • Seizures
 • Altered mental
Etiology: • Pathophysiology ... unclear, endothelial dysfunction ... Neurological symptoms ... the underlying cause ... Syndrome #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH)

High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
cytopenias and organ dysfunction ... hyperinflammatory syndrome caused ... Persistent fever, organ dysfunction ... Common Signs and Symptoms ... Pathophysiology