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diagnosis rheumatology differential management disease erythematosus fever hepatology hepatorenal hrs hypertension igg4 immunecompromised immunocompromised lupus nephrology phtn polychondritis proteins pulmonary
Subtypes of Serum Proteins Pre-albumin (Transthyretin) Albumin Globulins • Alpha-1: Alpha-1 antitrypsin, Serum amyloid A, Ceruloplasmin, Corticosteroid-binding globulin (Transcortin),
IgG, IgA, RF, CRP ... Proteins #Subtypes #algorithm ... #classification ... #Types #hematology
Clinical Classification of Pulmonary Hypertension 1. Pulmonary arterial hypertension from pulmonary vasculopathy Idiopathic pulmonary arterial hypertension Heritable gene mutations
Clinical Classification ... protein receptor type ... activin A receptor type ... multifactorial mechanisms Hematologic ... #Differential #Causes
Hepatorenal Syndrome (HRS) Definition: • Functional, potentially reversible kidney impairment. • Occurs in advanced liver disease: cirrhosis, severe alcoholic
• Caused by splanchnic ... Exclude other AKI causes ... Classification: ... Type 1): • Rapid ... Type 2): • Gradual
Von Willebrand Disease Classification Type 1 (Accounts for ~3/4 of cases): • Defect: Quantitative defect (i.e. not
Willebrand Disease Classification ... for ~3/4 of cases ... Qualitative defect (i.e. dysfunctional ... VonWillebrand #Disease #Classification ... #hematology
Causes of Fever in the Immunocompromised Host - Differential Diagnosis Algorithm Structural Defect - Asplenia/HypospIenism • Bacteremia/Septic
Causes of Fever ... Differential Diagnosis Algorithm ... jirovecii • CNS ... or Neutrophil Dysfunction ... #Causes #Hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Skin Disease Classification ... Malignancy (e.g. hematologic ... Kikuchi disease • Type-I ... mild cognitive dysfunction ... vein thrombosis Hematologic
IGG-4 RELATED DISEASE WHAT? • A chronic, immune-mediated fibroinflammatory disease with tumefactive infiltration of IgG4+ plasma cells
- Organ dysfunction ... progressive organ dysfunction ... • Pancreas: Type ... Thyroid (Riedel's), CNS ... complement • Classification
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
hearing loss, nausea ... insufficiency • Cognitive dysfunction ... Antibodies to type ... Nonspecific ↑ ESR, CRP ... Polychondritis #rheumatology
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