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diagnosis rheumatology differential management erythematosus fever hepatology hepatorenal hrs hypertension igg4 immunecompromised immunocompromised lupus nephrology phtn polychondritis pulmonary relapsing sle
Clinical Classification of Pulmonary Hypertension 1. Pulmonary arterial hypertension from pulmonary vasculopathy Idiopathic pulmonary arterial hypertension Heritable gene mutations
Clinical Classification ... protein receptor type ... activin A receptor type ... multifactorial mechanisms Hematologic ... #Differential #Causes
Von Willebrand Disease Classification Type 1 (Accounts for ~3/4 of cases): • Defect: Quantitative defect (i.e. not
Von Willebrand Disease ... Classification ... Qualitative defect (i.e. dysfunctional ... #Classification ... #hematology
Hepatorenal Syndrome (HRS) Definition: • Functional, potentially reversible kidney impairment. • Occurs in advanced liver disease: cirrhosis, severe alcoholic
advanced liver disease ... • Caused by splanchnic ... Classification: ... Type 1): • Rapid ... Type 2): • Gradual
IGG-4 RELATED DISEASE WHAT? • A chronic, immune-mediated fibroinflammatory disease with tumefactive infiltration of IgG4+ plasma cells
- Organ dysfunction ... progressive organ dysfunction ... • Pancreas: Type ... Thyroid (Riedel's), CNS ... complement • Classification
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: ... Malignancy (e.g. hematologic ... • Type-I Interferonopathies ... mild cognitive dysfunction ... vein thrombosis Hematologic
Causes of Fever in the Immunocompromised Host - Differential Diagnosis Algorithm Structural Defect - Asplenia/HypospIenism • Bacteremia/Septic
Causes of Fever ... jirovecii • CNS ... or Neutrophil Dysfunction ... • Periodontal Disease ... #Causes #Hematology
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
immunologically mediated diseases ... insufficiency • Cognitive dysfunction ... Sarcoidosis • Behcet disease ... Antibodies to type ... Nonspecific ↑ ESR, CRP
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