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diagnosis management hematology latenttb tb treatment tuberculosis hemophagocytic hlh lymphohistiocytosis rheumatology active amyloid amyloidosis clarkes differential erythematosus evaluation grind hemeonc
Clarke's Test (Patellar Grind Test) Indicates Patellofemoral dysfunction. - Patient with knee in extension. Push posterior on
Clarke's Test (Patellar ... Grind Test) ... Patellofemoral dysfunction ... patient to perform active ... Patellar #Grind #clinical
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 Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
Active: Symptomatic ... • Endogenous reactivation ... characteristic features Clinical ... Tuberculin skin test ... Inhibitor: • Risk of reactivation
Tuberculosis Testing LATENT TB • LTBI is diagnosed when an asymptomatic patient has a positive TST or IGRA
result with no clinical ... manifestations of active ... decrease the risk for reactivation ... of developing active ... years of age ACTIVE
Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
Active: Symptomatic ... • Endogenous reactivation ... characteristic features Clinical ... Tuberculin skin test ... Inhibitor: • Risk of reactivation
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
bowel or bladder dysfunction ... • Excessive activation ... Transverse Myelitis - Clinical ... negative, MOG-IgG test ... Herpes zoster, West
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... fever syndromes Clinical ... Fever is the main clinical ... nervous system (CNS) dysfunction ... Liver function tests
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... excessive macrophage activation ... genetic immune dysfunction ... absent NK cell activity
SEPSIS AND SEPTIC SHOCK DEFINITION AND PATHOPHYSIOLOGY • Sepsis: Life-threatening organ dysfunction due to a dysregulated host
Life-threatening organ dysfunction ... cytokines, complement activation ... CLINICAL RECOGNITION ... CLINICAL FEATURES ... and molecular tests
Preoperative Risk Evaluation Major Pre-Op Questions: 1. Does the patient have any modifiable risk factors that could be
Performance thorough ... determine if stress test ... with valvular dysfunction ... or LV dysfunction ... Change in clinical
Amyloidosis - Summary Group of disorders associated with extracellular deposition of fibrils formed from low-molecular-weight proteins in
Clinical suspicion ... Amyloidosis Clinical ... Dystrophy Heme: • ↓ activity ... Inflammation → Macrophage activation ... Testing Blood Tests
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