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diagnosis management differential hematology hemophagocytic hepatology hlh lymphohistiocytosis rheumatology syndrome abnormal disease enzymes hemeonc hemepath hepatorenal hrs incomplete kawasaki lfts
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... accumulation of clinical ... Assessment • Clinical ... , Hb), Hepatic dysfunction ... inhibitors under evaluation
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
function tests algorithm ... indicate the initial evaluation ... history alongside evaluation ... metabolic syndrome criteria ... LFTs #Abnormal #Algorithm
Evaluation of suspected incomplete Kawasaki Disease 1. AHA consensus recommendations 2. Infants ≤6 months old on day ≥7
Evaluation of suspected ... if they have no clinical ... purposes of this algorithm ... those >day 10 with clinical ... Disease #Incomplete #Algorithm
Guide to systemic mastocytosis Criteria for diagnosis: at least 1 major and 1 minor or 3 minor
mastocytosis Criteria ... minor or 3 minor criteria ... without organ dysfunction ... hemepath #pathology #algorithm ... #diagnosis #clinical
Preoperative Risk Evaluation Major Pre-Op Questions: 1. Does the patient have any modifiable risk factors that could be
Preoperative Risk Evaluation ... Performance thorough ... event, follow ACC algorithm ... or LV dysfunction ... Change in clinical
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... fever syndromes Clinical ... Fever is the main clinical ... nervous system (CNS) dysfunction ... Histopathologic criteria
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
bowel or bladder dysfunction ... • Excessive activation ... Transverse Myelitis - Clinical ... Autonomic Dysfunction ... Diagnostic Criteria
Hepatorenal Syndrome (HRS) Definition: • Functional, potentially reversible kidney impairment. • Occurs in advanced liver disease: cirrhosis, severe alcoholic
sympathetic + ADH activation ... Diagnosis (Clinical ... Criteria): • ↑ ... liver transplant evaluation
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
cytopenias and organ dysfunction ... Persistent fever, organ dysfunction ... Clinical Presentation ... Diagnostic Criteria ... of 8 HLH-2004 criteria
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